Solidarity Trial by The WHO: The Definitive Guide

Share on telegram
Share on facebook
Share on twitter
Table Of Contents


State Government of Tamil Nadu will be part of this trial, two centers have been chosen from the Tamil Nadu state.

Recently World Health Organisation caution against the physician and medical associations recommending or administrating the unproven treatments to the patients of COVID-19.

There are some incidences, such as people are self-medicating with tablets like hydroxychloroquine and causing themselves serious harms.

In this context, WHO and its partners came up with Solidarity Trial.

What is a solidarity trial?

Solidarity is an international randomized clinical trial to help find an effective treatment for COVID-19. As a part of this trial patients from multiple countries will be enrolled.

In randomized clinical trials, the participants are divided by chance into separate groups and these groups receive different treatment. And after this treatment, the results are compared to find the most effective treatment.

Aim of Trial

This trial aims to rapidly discover whether any drugs slow the disease progression or improve the survival of human beings, who are affected with COVID-19 and other drugs will be added in the due course based on emerging situations.

Solidarity trial will compare four treatment options, to asses their relative effectiveness against COVID-19.

Four Treatment Options

  1. Remdesivir
  2. Lopinavir or Ritonavir
  3. Lopinavir or Ritonavir with Interferon Beta-1A
  4. Chloroquine and Hydroxychloroquine


Remdesivir is previously tested as an Ebola treatment. It also generated promising results in animal studies for MERS and SARS. Understand that Middle-East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)both are caused by coronaviruses.

Lopinavir or Ritonavir

Lopinavir or Ritonavir is a licensed treatment for HIV-AIDS.

Lopinavir or Ritonavir with Interferon Beta-1A

Lopinavir or Ritonavir with Interferon Beta-1A is used to treat Multiple Sclerosis

Chloroquine and Hydroxychloroquine

Chloroquine and Hydroxychloroquine are used to treat Malaria and Rheumatology conditions respectively. That is Chloroquine is used for the treatment of Malaria and Hydroxychloroquine is used for the treatment of Rheumatology.


  • The pressure put on by COVID-19 disease on the health system forced the World Health Organisation to speed up the trial.
  • Randomized clinical trials normally take years to design and conduct and to arrive at the Results. Whereas this solidarity trial will reduce the time taken by eighty percentage (80%).
  • Because enrolling patients from different parts of the world in one single randomized trial will help facilitate the rapid worldwide comparison of unproven treatments.
  • If you see in small trials they will not generate strong evidence that is required to determine the relative effectiveness of potential treatments but with the help of this single randomized trial, this risk can be awoken.

Benefits of solidarity Trail

  • As per the World health organization trail provide solidarity trail to provide simplified procedures to enable even overloaded hospitals to participate with no paperwork required.
  • As of now April 2020, over Hundred (100) countries are working together to find and effective therapeutics as soon as possible via this solidarity trial.
  • So the greater the number of participating countries the faster the results will be generated.

Action taken By WHO

  • WHO is facilitating access to thousands of treatment courses for the trial through donations from a number of manufacturers.
  • WHO also inviting developers and companies to collaborate on ensuring affordability and availability of treatment options if they proved effective.

Criteria for Patients Enrolment on The Clinical Trials Registry of India (CTRI):

  • Patients should be adults aged 10 or above and not receiving any of the study drugs already.
  • People without know allergy to any of the study drugs.
  • Patients with chronic liver or heart disease, pregnant women, and those who do not wish to participate in the study cannot be recruited.

for more Science and technology articles click here.

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top